Three-Dimensional Bioprinting of Thick Vascularized Tissues
Investigators report a method for bioprinting three dimensional cell-laden, vascularized tissues that exceed 1 cm in thickness and can be perfused on chip for long time periods. They integrated parenchyma, stroma, and endothelium into a single thick tissue by coprinting multiple inks composed of human mesenchymal stem cells and human neonatal dermal fibroblasts within a customized extracellular matrix alongside embedded vasculature, which is subsequently lined with human umbilical vein endothelial cells. [Proc Natl Acad Sci USA] Full Article|Press Release|Video
Urine of Preterm Neonates as a Novel Source of Kidney Progenitor Cells
Neonatal stem/progenitor cells expressed markers of nephron progenitors but also, stromal progenitors, with many single cells coexpressing these markers. Furthermore, these cells presented mesenchymal stem cell features and protected cocultured tubule cells from cisplatin-induced apoptosis. [J Am Soc Nephrol] Abstract|Press Release
A Novel Therapeutic Approach Using Mesenchymal Stem Cells to Protect against Mycobacterium abscessus
Scientists demonstrated the use of mesenchymal stem cells (MSCs) as a novel therapeutic strategy against M. abscessus, which is the most drug-resistant and difficult-to-treat mycobacterial pathogen. The systemic intravenous injection of MSCs not only improved mouse survival but also enhanced bacterial clearance in the lungs and spleen. [Stem Cells] Abstract
Immunomodulatory Functions of Mesenchymal Stem Cells and Possible Mechanisms
The authors review the studies on the immunomodulatory and anti-inflammatory functions of mesenchymal stem cells (MSCs) and the mechanisms responsible for the interaction between immune cells and MSCs, which could improve the development of promising approaches for cell-mediated immune therapies. [Histol Histopathol] Abstract
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INDUSTRY NEWS
Amedica and Celling Biosciences to Collaborate on Biologically Enhanced Spinal Fusion Devices
Amedica Corporation announced a collaboration with Celling Biosciences to research and develop biologically enhanced implants. As part of the initial phase of the collaboration, Celling Biosciences’ team of scientists produced research indicating mesenchymal stem cells can be optimized and proliferate when using silicon nitride compared to the current PEEK and titanium biomaterial standards. [Amedica Corporation] Press Release
$20 Million Gift Will Help Make Research Institute a Reality
An anonymous racehorse breeder has donated $20 million to Colorado State University to build a state-of-the-art regenerative medicine research facility, fulfilling a $65 million matching challenge from lead donors and fellow horse aficionados John and Leslie Malone. In December 2014, the Malones pledged a record-breaking $42.5 million for the planned facility, prompted by their interest in stem-cell therapy and its effectiveness in treating equine joint problems. [Colorado State University] Press Release
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