Volume 8.14 | Apr 12

Mesenchymal Cell News 8.14 April 12, 2016
Mesenchymal Cell News
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Increased Survival and Function of Mesenchymal Stem Cell Spheroids Entrapped in Instructive Alginate Hydrogels
In order to assess the contribution of adhesivity on spheroid activity in engineered materials and promote the bone-forming potential of mesenchymal stem cells (MSCs), scientists compared the function of MSC spheroids when entrapped in Arg-Gly-Asp-modified alginate hydrogels to nonfouling unmodified alginate. [Stem Cells Transl Med] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)

The Supportive Role of Insulin-Like Growth Factor-I in the Differentiation of Murine Mesenchymal Stem Cells into Corneal-Like Cells
This study was focused on characterizing the differentiation of bone marrow-derived mesenchymal stem cells (MSCs) into corneal-like cells. Mouse MSCs were isolated from the bone marrow, grown in cell culture for three weeks and purified using a magnetic activated cell sorter. Purified MSCs were cultured with an extract prepared from excised corneas and in the presence or absence of insulin-like growth factor-I. [Stem Cells Dev] Abstract

Differentiation of Hepatocytes from Induced Pluripotent Stem Cells Derived from Human Hair Follicle Mesenchymal Stem Cells
Investigators explored whether mesenchymal stem cells separated from human hair follicles (HF-MSCs) and HF-MSC-derived-induced pluripotent stem cells could differentiate into hepatocytes in vitro. [Cell Tissue Res] Abstract

Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells Expressing Elastin Alleviates Pelvic Floor Dysfunction
In an in vitro cell culture system of seven days, when no additional bFGF was administrated, the initial poly (lactic-co-glycolic acid)-loaded bFGF nanoparticle induced prolonged production of collagen and elastin from elastin-expressing bone marrow-derived mesenchymal stem cells. [Stem Cell Res Ther] Abstract

Spontaneous Differentiation of Human Mesenchymal Stem Cells on Poly-Lactic-Co-Glycolic Acid Nano-Fiber Scaffold
The authors investigated the osteogenesis and chondrogenesis potentials of mesenchymal stem cells seeded onto nano-fiber scaffolds in vitro and possible use for the repair of rheumatoid arthritis-affected joints. [PLoS One] Full Article

Microvesicles Enhance the Mobility of Human Diabetic Adipose Tissue-Derived Mesenchymal Stem Cells In Vitro and Improve Wound Healing In Vivo
Researchers characterized non-diabetic adipose tissue-derived mesenchymal stem cell (nAT-MSC)-derived microvesicles (MVs) and their function after the transfection of diabetic adipose tissue derived (dAT)-MSCs with MVs using the scratch assay and a flap mouse model. The authors found that human nAT-MSC-derived MVs expressed MSC-surface markers and improved dAT-MSC functions by altering the expression of genes associated with cell migration, survival, inflammation, and angiogenesis as well as miR29c and miR150. [Biochem Biophys Res Commun] Abstract


Bone-Marrow-Derived Mesenchymal Stem Cells Inhibit Gastric Aspiration Lung Injury and Inflammation in Rats
Researchers investigated the effects of bone-marrow-derived mesenchymal stem cells (BMSCs) on combined acid plus small non-acidified particle (CASP)-induced aspiration lung injury. Enhanced green fluorescent protein (EGFP+) or EGFP BMSCs or 15d-PGJ2 were injected via the tail vein into rats immediately after CASP-induced aspiration lung injury. [J Cell Mol Med] Abstract

Discrepant Results of Experimental Human Mesenchymal Stromal Cell Therapy after Myocardial Infarction: Are Animal Models Robust Enough?
Researchers investigated the effect of intramyocardial injection of human mesenchymal stromal cells pre-stimulated with the pro-inflammatory cytokine interferon-gamma, since pro-inflammatory priming has shown additional salutary effects in multiple experimental disease models. [PLoS One] Full Article

Immune Modulation with Primed Mesenchymal Stem Cells Delivered via Biodegradable Scaffold to Repair an Achilles Tendon Segmental Defect
The in vivo healing effects of TNF-α primed mesenchymal stem cells (MSCs) were studied using a rat Achilles segmental defect model. Rat Achilles tendons were subjected to a unilateral 3 mm segmental defect and repaired with either a PLG scaffold alone, MSC-seeded PLG scaffold, or TNF-α-primed MSC-seeded PLG scaffold. [J Orthop Res] Abstract

Intratracheal Transplantation of Mesenchymal Stem Cells Simultaneously Attenuates both Lung and Brain Injuries in Hyperoxic Newborn Rats
The authors investigated whether attenuation of hyperoxic lung injury with intratracheal transplantation of human umbilical cord blood-derived mesenchymal stem cells could simultaneously mitigate brain damage in neonatal rats. [Ped Res] Abstract

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Advances in Combining Gene Therapy with Cell and Tissue Engineering-Based Approaches to Enhance Healing of the Meniscus
Combining gene-, cell-, and tissue engineering-based approaches is an attractive strategy to generate novel, effective therapies to treat meniscal lesions. The authors provide an overview of the tools currently available to improve meniscal repair and discuss the progress and remaining challenges for potential future translation in patients. [Osteoarthritis Cartilage] Abstract

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Cynata Reports Compelling Results from Pre-Clinical Stem Cell Study in Graft-versus-Host Disease (GvHD)
Cynata Therapeutics Limited has received extremely positive interim data from a proof of concept study of its lead Cymerus mesenchymal stem cell product, CYP-001. [Cynata Therapeutics Limited] Press Release

Clinical Trial Involving Regenerative Cell Treatment for Patients with Traumatic Brain Injury Permitted in Japan
SanBio, Inc. announced that they are now able to conduct the world’s first global Phase II clinical trial for chronic traumatic brain injury with allogeneic stem cells in Japan. [SanBio, Inc.] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Changing the Face of Modern Medicine: Stem Cells & Gene Therapy
October 18-21, 2016
Florence, Italy

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NEW Engineering Project Lead (Cytonome)

Research Technologist – Mesenchymal Stem Cell Biology (STEMCELL Technologies Inc.)

Postdoctoral Training Fellow – Molecular and Stem Cell Biology (The Francis Crick Institute)

Postdoctoral Research Associate – Stem Cell Biology and Cell Differentiation (University of Illinois Chicago College of Medicine)

Postdoctoral Position – Epigenetic Regulation of Cell Fate, Cancer and Metabolism (University Medical Center Freiburg)

Postdoctoral Fellow – Mechanoregulation of Fibrosis and Vascular Injury (St. Michael’s Hospital)

Cell Culture Technician (California Institute of Technology)

Postdoctoral Positions – Tissue Repair/Inflammation (Institut Pasteur)

Two Early Stage Researchers/PhD Fellowships – Tendon Therapy (NUI Galway)

Independent Group Leaders – Regenerative Medicine (Center of Regenerative Medicine in Barcelona)

Tenure-Track Faculty Positions – Assistant/Associate/Full Professor (Nanyang Technological University)

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