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Mesenchymal Cell News
Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.
Design of a Stem Cell–Based Therapy for Ependymal Repair in Hydrocephalus Associated with Germinal Matrix Hemorrhages
[Stroke] Investigators explored the possibilities of ependymal repair in GMH/PHH using a combination of neural stem cells, ependymal progenitors, and mesenchymal stem cells.
Oncogene-Induced Matrix Reorganization Controls CD8+ T Cell Function in the Soft-Tissue Sarcoma Microenvironment
[European Journal Of Clinical Investigation] Scientists investigated how ECM composition modulated CD8+ T cell function in undifferentiated pleomorphic sarcoma, an immunologically active desmoplastic tumor.
Nonlinear Elastic Bottlebrush Polymer Hydrogels Modulate Actomyosin Mediated Protrusion Formation in Mesenchymal Stromal Cells
[Advanced Materials] Bottlebrush polymers were synthesized and crosslinked to form poly(ethylene glycol)-based hydrogels and used to study how strain-stiffening behavior affects human MSCs.
Defining Mesenchymal Stem/Stromal Cell-Induced Myeloid-Derived Suppressor Cells Using Single-Cell Transcriptomics
[Molecular Therapy] The authors revealed seven distinct immune cell types including myeloid-derived suppressor cells in the CD11bmidLy6Cmid cells, while CD11bhiLy6Chi cells included mostly monocytes/macrophages with a small cluster of neutrophils.
Transcriptomic and Cellular Decoding of Scaffolds-Induced Suture Mesenchyme Regeneration
[International Journal Of Oral Science] Investigators' data elucidated the natural processes without scaffold transplantation and demonstrated how different scaffolds altered in vivo cellular responses.
Mesenchymal Stem Cells Derived-Exosomes Enhanced Amniotic Membrane Extract Promotes Corneal Keratocyte Proliferation
[Biotechnology Progress] The authors evaluated the effects of both amniotic membrane extract and Wharton's jelly MSC derived-exosomes, individually and together, on the proliferation of corneal keratocytes as well as their ability to promote in vitro cell migration, wound healing, and their impact on cellular morphology.
PPARγ Inhibition Promotes Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells and Fracture Healing
[Journal Of Cellular Biochemistry] Bone healing processes in the rat femur fracture model were recorded and assessed by radiographic methods on Weeks 8, 14, and 20 postoperation.
NIH Grant Supports Additional Baby Metabolism Research
[East Carolina University] A five-year, $2.5 million R01 grant from the National Institutes of Health will help East Carolina University faculty members continue research on ways to curb generational obesity.
Mesenchymal Stem Cells as Therapeutic Vehicles for Glioma
[Cancer Gene Therapy] MSCs exhibit advantages for glioma therapy because of their ability to pass through the blood–brain barrier and migrate to tumor cells and their tolerance to the immune system.
Transcriptome and Single-Cell Analysis Reveal Disulfidptosis-Related Modification Patterns of Tumor Microenvironment and Prognosis in Osteosarcoma
[Scientific Reports] Scientists investigated disulfidptosis-related modification patterns in osteosarcoma (OS) and their relationship with survival outcomes in patients with OS.
Mitochondrial Enzyme FAHD1 Reduces ROS in Osteosarcoma
[Scientific Reports] Scientists investigated the impact of overexpressing the mitochondrial enzyme Fumarylacetoacetate hydrolase domain-containing protein 1 (FAHD1) in human osteosarcoma epithelial cells in vitro.
The IL-6 Signaling Pathway Contributes Critically to the Immunomodulatory Mechanism of Human Decidua-Derived Mesenchymal Stromal Cells
[iScience] Researchers found that knock-down IL-6 in decidua-derived MSCs reduced the expression of PD-L1 and PD-L2, which are known as classical immune checkpoint inhibitors.
Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.
